UJI TOKSISITAS HASIL FRAKSINASI EKSTRAK DAUN GANDARIA (Bouea macrophylla Griff) TERHADAP LARVA UDANG (Artemia salina Leach) DENGAN METODE BSLT (Brine Shrimp Lethality Test)
DOI:
https://doi.org/10.51225/jps.v9i1.105Keywords:
antikanker, daun gandaria, BSLTAbstract
Bouea macrophylla Griff (gandaria) is a rare fruit plant native to Maluku that possesses scientific potential which has not been widely explored. Its leaves contain quercetin, a flavonoid known to have antioxidant, anti-inflammatory, anticancer, antimicrobial, cardioprotective, and antidiabetic effects at non-toxic doses. This study evaluated the toxicity of leaf extract fractions in ethanol, ethyl acetate, and n-hexane solvents using the Brine Shrimp Lethality Test (BSLT) to determine the LC₅₀ value against Artemia salina larvae. The results showed that the n-hexane and ethanol fractions were toxic, with LC₅₀ values of 61.66 µg/mL and 170.61 µg/mL, respectively, while the ethyl acetate fraction exhibited much lower toxicity (LC₅₀ = 1425.61 µg/mL). This study indicates that the n-hexane and ethanol fractions have significant cytotoxic activity and therefore have the potential to inhibit cancer cell growth.
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Copyright (c) 2025 Wahyu Nuraini Hasmar, Michelia Victoria, Nurul Inayah, Tamzil Azizi Musdar, Ika Lismayani Ilyas , Muhammad Israwan Aziz
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