https://www.journal.stisadwifarma.ac.id/index.php/jps/issue/feed Journal Pharma Saintika 2025-11-29T08:54:47+07:00 Apt. Mhd. Riza Marjoni, S.Si, M.Farm Marjoni@akfardwifarma.ac.id Open Journal Systems <div style="border: 3px #086338 Dashed; padding: 10px; background-color: #a0d9f6; text-align: left;"> <ol> <li><strong>Journal Title </strong>: Jurnal Pharma Saintika</li> <li><strong>Initials </strong>: JPS</li> <li><strong>Frequency </strong>: April dan Oktober</li> <li><strong>Online ISSN </strong>: <a href="https://issn.brin.go.id/terbit/detail/1491279795">2580-684X</a></li> <li><strong>Editor in Chief </strong>: -</li> <li><strong>DOI </strong>: 10.51225</li> <li><strong>Publisher </strong>: Program Studi DIII Farmasi Akademi Farmasi Dwi Farma</li> </ol> </div> <p style="text-align: justify;"><strong>Jurnal Pharma Saintika</strong> dengan e-ISSN : <a href="https://issn.brin.go.id/terbit/detail/1491279795">2580-684X</a>, merupakan jurnal elektronik nasional yang merupakan wadah penerbitan artikel penelitian original yang terkait dengan penelitian Farmasi. Jurnal ini dikelola oleh Program Studi DIII Farmasi Akademi Farmasi Dwi Farma. Jurnal ini diterbitkan dua kali dalam setahun dibulan <strong>April dan Oktober</strong>. Jurnal ini menyajikan hasil penelitian dibidang Farmasi.Jurnal ini bertujuan untuk menjembatani kesenjangan antara penelitian dan praktik, memberikan informasi, ide-ide dan pendapat, selain analisis kritis kemajuan dalam penelitian Farmasi. Melalui cakupan perkembangan kebijakan dan kurikulum, hasil terbaru dari penelitian serta aplikasinya dalam pengajaran, pembelajaran dan penilaian farmasi dimasa yang akan datang. Penekanan khusus ditempatkan pada penelitian yang relevan dengan praktek pendidikan, dipandu oleh realitas pendidikan dalam sistem, sekolah, perguruan tinggi dan universitas.</p> <div> <p style="text-align: justify;"><strong style="font-size: 0.875rem;">Indexed by :</strong></p> <div> <table style="height: 133px;" width="687"> <tbody> <tr> <td style="width: 132.275px;"><a title="scholar.google" href="https://scholar.google.com/citations?hl=id&amp;user=3SCxvtkAAAAJ&amp;view_op=list_works&amp;authuser=3&amp;sortby=pubdate" target="_blank" rel="noopener"><img src="https://app.apji.org/assets/side-logo/GoogleScholar.jpg" /></a></td> <td style="width: 132.275px;"><a title="indexcopernicus" href="https://journals.indexcopernicus.com/search/details?id=131069&amp;lang=en" target="_blank" rel="noopener"><img src="https://app.apji.org/assets/side-logo/copernicus.png" /></a></td> <td style="width: 132.275px;"><a title="garuda" href="https://garuda.kemdikbud.go.id/journal/view/33571" target="_blank" rel="noopener"><img src="https://app.apji.org/assets/side-logo/Garuda.jpg" /></a></td> <td style="width: 132.275px;"><a title="sinta5" href="https://sinta.kemdikbud.go.id/journals/?q=pharma%20saintika" target="_blank" rel="noopener"><img src="https://journal.akfardwifarma.ac.id/public/site/images/rama/untitled-design.png" /></a></td> <td style="width: 132.3px;"> </td> </tr> <tr> <td style="width: 132.275px;"><a title="crossref" href="https://search.crossref.org/search/works?q=Jurnal+Pharma+Saintika&amp;from_ui=yes" target="_blank" rel="noopener"><img src="https://app.apji.org/assets/side-logo/logo-crossref.png" /></a></td> <td style="width: 132.275px;"><a title="orcid" href="https://orcid.org/0009-0005-1723-6698" target="_blank" rel="noopener"><img src="https://app.apji.org/assets/side-logo/LOGO%20ORCID.png" /></a></td> <td style="width: 132.275px;"><a title="dimensions" href="https://app.dimensions.ai/discover/publication?search_mode=content&amp;viz-st:aggr=mean&amp;search_text=10.51225&amp;search_type=kws&amp;search_field=full_search&amp;or_facet_source_title=jour.1460922" target="_blank" rel="noopener"><img src="https://app.apji.org/assets/side-logo/dimension.png" /></a></td> <td style="width: 132.275px;"><a title="scilit" href="https://www.scilit.net/sources/140681" target="_blank" rel="noopener"><img src="https://app.apji.org/assets/side-logo/logo-scilit.png" /></a></td> <td style="width: 132.3px;"> </td> </tr> </tbody> </table> </div> <div> <p><strong style="font-size: 0.875rem;">Journal Sponsors and Partners :</strong></p> </div> <div> <table style="height: 133px;" width="688"> <tbody> <tr> <td style="width: 132.275px;"><a title="apji" href="https://apji.org/jurnalinfo?p=dFMwNm9TV1cxeW1KbjdsZzZXeDFRdz09" target="_blank" rel="noopener"><img src="https://app.apji.org/assets/side-logo/logo_APJI.jpg" /></a></td> <td style="width: 132.275px;"><a title="arikesi" href="https://arikesi.or.id/jurnalinfo?p=dFMwNm9TV1cxeW1KbjdsZzZXeDFRdz09" target="_blank" rel="noopener"><img src="https://app.apji.org/assets/side-logo/logo_ARIKESI.jpg" /></a></td> <td style="width: 132.275px;"><a style="color: #008acb;" title="doi.apji" href="https://doi.apji.org/publisher" target="_blank" rel="noopener"><img src="https://app.apji.org/assets/side-logo/doi-apji.png" /></a></td> <td style="width: 132.275px;"> </td> <td style="width: 132.3px;"> </td> </tr> <tr> <td style="width: 132.275px;"><a style="color: #008acb;" title="yayasandpi" href="https://yayasandpi.or.id/" target="_blank" rel="noopener"><img src="https://app.apji.org/assets/side-logo/logo_015.jpg" /></a></td> <td style="width: 132.275px;"><a style="color: #008acb;" title="ifrel" href="https://ifrel.org/" target="_blank" rel="noopener"><img src="https://app.apji.org/assets/side-logo/side-logo-ifrel.jpg" /></a></td> <td style="width: 132.275px;"><a style="color: #008acb;" title="lpkd" href="https://lpkd.or.id/" target="_blank" rel="noopener"><img src="https://app.apji.org/assets/side-logo/logo_LPKD.jpg" /></a></td> <td style="width: 132.275px;"> </td> <td style="width: 132.3px;"> </td> </tr> </tbody> </table> </div> </div> https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/81 HUBUNGAN BAURAN PEMASARAN (MARKETING MIX) DENGAN OMSET APOTEK: TINJAUAN LITERATUR 2025-08-21T07:17:15+07:00 Meridona apotekermeridona@gmail.com Seftika Sari seftikasari@stifar-riau.ac.id Neni Frimayanti nenifrimayanti@stifar-riau.ac.id <p><strong><em>Abstract</em></strong><strong>: </strong><em>In recent years, the pharmaceutical and healthcare industries have undergone significant changes, marked by increasing competition among service providers, including pharmacies. Pharmacies must adapt their marketing plans in response to regulatory changes, service digitization, and increasing public health awareness. The purpose of this study is to conduct a systematic review of the existing literature on the relationship between pharmacy turnover success and marketing mix tactics. Databases including Google Scholar, PubMed, and Sciencedirect were searched, analyzing English and Indonesian-language publications published between 2015 and 2025 using the PRISMA method for systematic literature review. Of the 745 articles found, five were eligible for inclusion and further analysis. The results indicate that the key elements of the 7Ps of marketing—competitive pricing, product availability, and high-quality service involving both human resources and processes—have a significant impact on purchasing decisions and consumer loyalty. The study suggests that digital-based marketing initiatives and consumer education are important complementary elements in improving pharmacy performance. Overall, this study concludes that to maximize pharmacy turnover and competitiveness in the ever-changing healthcare environment, the 7P marketing mix must be implemented in an integrated and customer-oriented manner.</em></p> 2025-09-22T00:00:00+07:00 Copyright (c) 2025 Meridona, Seftika Sari, Neni Frimayanti https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/61 PENETAPAN KADAR SARI LARUT AIR DAN SARI LARUT ETANOL SIMPLISIA DAUN KERSEN (Muntingia calabura L.) 2025-06-11T14:25:07+07:00 Nadania Issnann Romadhani nadaniaissnannromadhani17@gmail.com Fara Azzahra faraazzahra@afi.ac.id Octariana Sofyan octariana.s@afi.ac.id <p><strong><em>Abstract</em></strong><strong>: </strong><em>The kersen </em><em>le</em><em>aves</em> <em>contain of chemical compounds such as a flavonoids, alkaloids, tannins and saponin. Standardization of kersen leaves is needed because of great potential inside it. One of standardization is testing the moisture content, water-soluble extract content, and ethanol-soluble extract content of kersen leaves simplicia. </em><em>This </em><em>research</em><em> aims to determine the moisture content, water-soluble extract content, and ethanol-soluble extract content of kersen leaves </em><em>simplicia</em><em>. The method used in this </em><em>research</em><em> is the </em><em>p</em><em>osttest </em><em>o</em><em>nly </em><em>d</em><em>esign. </em><em>The k</em><em>ersen leaves are dried in an oven at 50°C for 24 hours</em><em> and </em><em>then </em><em>be mashed </em><em>using a grinder and sieved until they become powder. The testing of moisture content, water-soluble extract content, and ethanol-soluble extract content was conducted using the gravimetric method. The test results were analyzed descriptively and compared with previous literature. The</em><em> result of</em><em> average moisture content </em><em>on</em><em> kersen leaves was 6.15±0.03%; the water-soluble extract and ethanol-soluble extract of kersen leaves were 4.05±0.09% and 5.75±0.05%.</em><em> Based on</em> <em>t</em><em>he results </em><em>showed that </em><em>the moisture content of kersen leaves has complied with the requirements of &lt;10%. Meanwhile, the ethanol-soluble extract content of </em><em>k</em><em>ersen leaves </em><em>has </em><em>higher than the water-soluble extract content, </em><em>this concluded that a</em><em> co</em><em>ntent</em><em> of kersen leaves </em><em>has</em><em> non-polar</em> <em>characteristic</em><em>.</em></p> 2025-09-23T00:00:00+07:00 Copyright (c) 2025 Fara Azzahra, Nadanisa Issnann Romadhani, Octariana Sofyan https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/88 PERAN TABLET CURCUMA DALAM MENURUNKAN RISIKO HEPATOTOKSISITAS PADA PASIEN TB PARU YANG MENJALANI TERAPI OAT DI RS PASAR REBO KOTA JAKARTA TIMUR 2025-09-13T08:56:38+07:00 Dini Permata Sari dini.sari@uta45jakarta.ac.id Nhila Putri Evani nhilaputrii07@gmail.com Rangki Astiani veronica.rangki@gmail.com <p><strong><em>Abstract</em>: </strong><em>Curcuma is known to play a role in preventing the side effects of anti-tuberculosis drugs (OAT), including hepatotoxicity, by protecting liver cells from oxidative stress and inflammation induced by drugs. The objective of this study was to determine the relationship between Curcuma tablet supplementation and the level of liver damage (hepatotoxicity), as measured by AST, ALT, and total bilirubin levels in pulmonary tuberculosis patients at Pasar Rebo Hospital. This study was non-experimental and classified as an analytical study with a cross-sectional approach. Data collection was conducted retrospectively, by reviewing past medical data and events. The sample in this study consisted of a portion of pulmonary tuberculosis patients undergoing OAT therapy at Pasar Rebo Hospital, East Jakarta, during the period of January–December 2024. The results showed that Curcuma tablet supplementation provided significant benefits to the liver health of pulmonary TB patients, as indicated by a statistically significant decrease in AST, ALT, and total bilirubin levels (p &lt; 0.05) after treatment. This decrease in liver enzyme and bilirubin levels reflects improved hepatic function and reduced hepatotoxicity. Thus, Curcuma tablets have been proven effective as a hepatoprotective agent in the context of OAT therapy..</em></p> 2025-09-22T00:00:00+07:00 Copyright (c) 2025 Dini Permata Sari, Nhila Putri Evani, Rangki Astiani https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/90 ANALISIS POLA DAN EFEKTIVITAS TERAPI ANTIBIOTIK EMPIRIS TERHADAP PERBAIKAN KLINIS PADA PASIEN KERATITIS BAKTERIAL RAWAT JALAN 2025-09-18T17:33:40+07:00 Widya Ari Sandi widyaarisandi8@gmail.com Seftika Sari SeftikaSari@mail.com Neni Frimayanti NeniFrimayanti@mail.com <p><strong><em>Abstract</em></strong><em>. Bacterial keratitis is a corneal infection that may lead to pain, visual impairment, and even permanent blindness if not promptly and appropriately treated. In outpatient settings, empirical antibiotic therapy is often chosen as the initial management because culture and sensitivity results require more time, whereas delays in therapy may worsen the clinical condition. This study aims to evaluate the effectiveness of empirical antibiotic therapy on clinical improvement and follow-up visits in patients with bacterial keratitis. A systematic literature review was conducted by searching PubMed and Google Scholar for articles published between 2015 and 2025. From 242 articles identified, 12 met the inclusion criteria and were analyzed further. The findings revealed that moxifloxacin and ciprofloxacin were the most frequently prescribed topical antibiotics, with treatment durations ranging from 7 to 21 days. Overall, empirical therapy was shown to accelerate clinical improvement, particularly within the first week of treatment. However, evidence supporting a reduction in follow-up visit frequency remains limited and presents varied results across studies, potentially due to differences in study design and patient conditions. Factors such as treatment regimen, duration of therapy, disease severity, and patient characteristics were also reported to influence the variability in outcomes. In conclusion, empirical antibiotic therapy appears to be clinically effective for bacterial keratitis. Nevertheless, to obtain a more comprehensive understanding of its impact on follow-up visits and implications for outpatient services in Indonesia, further research with larger sample sizes and prospective study designs is require</em><em>d.</em></p> 2025-09-23T00:00:00+07:00 Copyright (c) 2025 Widyaari Sandi, Seftika Sari, Neni Frimayanti https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/94 SKRINING FITOKIMIA, AKTIVITAS ANTIOKSIDAN DAN TOKSISITAS AKUT INFUSA BIJI DAN PERIKARP BUAH OLAE (Etlingera calophrys) 2025-10-18T09:01:41+07:00 Diah Astari Salam diahastari98@gmail.com Carla Wulandari Sabandar carla@usn.ac.id Ummul Fausiah UmmulFausiah1@mail.com Harni Sartika Kamaruddin HarniSartikaKamaruddin@mail.com Megawati Megawati@mgail.com Nisrina Muslihin NisrinaMuslihin@mail.com <p style="font-weight: 400;"><em>Olae (Etlingera calophrys), an endemic of Southeast Sulawesi, Indonesia, is traditionally used as a culinary spice and medicine, yet remains scientifically underexplored. This study investigated the phytochemical composition, antioxidant activity, and acute toxicity of infusion extract from the seeds and fruit pericarp. Phytochemical screening was performed using specific color reagents, antioxidant activity was evaluated with the 2.2-diphenyl-1-picrylhydrazyl (DPPH) method, and acute toxicity was assessed by the Brine Shrimp Lethality Test (BSLT) against Artemia salina. The seed infusion contained alkaloids and phenolics, while the pericarp infusion contained tannins and phenolics. Antioxidant testing revealed very strong radical scavenging activity, with SC₅₀ values of 0.05 g/100 mL (seeds) and 0.04 g/100 mL (pericarp). Toxicity testing indicated no significant toxicity, with LC₅₀ values of 1740 g/100 mL (seeds) and 2510 g/100 mL (pericarp). These findings suggest that infusion extract of E. calophrys possess strong antioxidant potential and are safe for use, supporting their prospective application as natural antioxidant sources.</em></p> 2025-10-01T00:00:00+07:00 Copyright (c) 2025 Diah Astari Salam, Carla Wulandari Sabandar, Ummul Fausiah, Harni Sartika Kamaruddin, Megawati, Nisrina Muslihin https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/96 AKTIVITAS ANTIMITOSIS EKSTRAK ETANOL 80% LAWI-LAWI (Caulerpa racemosa) TERHADAP SEL ZIGOT BULU BABI (Tripneustes gratilla) 2025-10-23T09:34:12+07:00 Eva Feriadi feriadi.eva@gmail.com Al Awaldhi Ramadhan AlAwaldhiRamadhan@mail.com Muh. Syahruddin Muh.Syahruddin1@mail.com Febrianto Patulak FebriantoPatulak@mail.com Diah Fausiah DiahFausiah@mail.ocm <p style="font-weight: 400;"><em>Cancer remains one of the leading causes of mortality worldwide, characterized by a high prevalence rate and ranking as the second most common cause of death globally. The elevated prevalence of cancer is closely associated with its hallmark features of uncontrolled cellular proliferation and aberrant mitotic processes. One plant species proposed to possess antimitotic potential is the lawi-lawi plant (Caulerpa racemosa). The bioactive compounds contained within this alga have been demonstrated to exhibit diverse pharmacological activities and are traditionally utilized by Indonesian communities as a natural source of antioxidants. This study employed a quantitative approach using a true experimental post-test-only control group design to evaluate the effect of an 80% ethanol extract of C. racemosa on the inhibition of mitosis in sea urchin (Tripneustes gratilla) zygote cells. The results of the antimitotic assay revealed that the C. racemosa extract exhibited an IC₅₀ value of 208.93 µg/mL, whereas the positive control, Vincristine, demonstrated a markedly lower IC₅₀ value of 2.46 µg/mL. These findings indicate that the 80% ethanol extract of C. racemosa possesses measurable antimitotic activity, although its potency is moderate when compared with the strong inhibitory effect exhibited by Vincristine.</em></p> 2025-10-01T00:00:00+07:00 Copyright (c) 2025 Eva Feriadi, Al Awaldhi Ramadhan, Muh. Syahruddin, Febrianto Patulak, Diah Fausiah https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/99 Motivasi sebagai Faktor Pendorong Kepatuhan Pengobatan pada Pasien Tuberkulosis. 2025-10-30T13:31:14+07:00 Fika Rizqiyana fikarizqiyana@gmail.com Widiya Nurhikmah WidiyaNurhikmah@mail.com Desi Sri Rejeki DesiSriRejeki@mail.com <p>Tuberculosis (TB) remains a major public health concern that requires long-term treatment with Anti-Tuberculosis Drugs (ATDs). The success of therapy largely depends on patient’s adherence to the prescribed regimen, which is influenced by various behavioral and psychosocial factors<em>. </em>This study aimed to determine the level of medication adherence among TB patients taking ATDs and analyze the factors influencing adherence, including knowledge, motivation, and social support. A descriptive quantitative study with a cross-sectional was conducted involving 43 respondents selected through total sampling. Data were collected using the Morisky Medication Adherence Scale 8 (MMAS-8) and questionnaires assessing knowledge, motivation, and social support. The findings showed that 41,9% patients had low adherence, 25,6% had moderate adherence, and 32,6% had high adherence. Of the three factors analyzed, ony motivation exhibited a statistically significant association with adherence (<em>p= </em>0,038), while knowledge (<em>p=</em>0,757) and social support (<em>p=</em>0,216) did not show significant associations. In conclusion, motivation represents a major determinant of adherence among TB patients. Interventions that emphasize motivational enhancement and educational engangement by healthcare providers should be prioritized to improve adherence and optimize treatment outcomes for tuberculosis.</p> 2025-10-01T00:00:00+07:00 Copyright (c) 2025 Fika Rizqiyana, Widiya Nurhikmah, Desi Sri Rejeki https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/92 EFEKTIVITAS PENGGUNAAN OBAT KEMOTERAPI NEOADJUVANT PADA PASIEN KANKER PAYUDARA DI RSUP FATMAWATI JAKARTA 2025-10-01T09:38:07+07:00 Dea Fauziah fauziahdea22@gmail.com Fajar Amirulah fajar.amirulah12@gmail.com Dini Permata Sari DiniPermataSari@mail.com Rangki Astiani RangkiAstiani@mail.com <p>Kanker payudara merupakan jenis kanker yang paling sering menyerang wanita dan menjadi penyebab utama kematian akibat kanker di Indonesia. Salah satu bentuk terapi utama adalah kemoterapi neoadjuvant yang diberikan sebelum pembedahan untuk mengecilkan ukuran tumor. Penelitian ini bertujuan mengevaluasi efektivitas kemoterapi neoadjuvant pada pasien kanker payudara stadium III di RSUP Fatmawati Jakarta berdasarkan perbedaan ukuran tumor sebelum dan sesudah terapi. Penelitian menggunakan desain deskriptif analitik retrospektif dengan data sekunder dari rekam medis pasien periode Januari 2023–Desember 2024. Sampel berjumlah 60 pasien yang memenuhi kriteria inklusi dan menerima regimen kombinasi CAF serta AC-T. Hasil menunjukkan adanya penurunan ukuran tumor yang signifikan, dari rata-rata 6,24 cm sebelum terapi menjadi 3,91 cm sesudah terapi. Uji Wilcoxon Signed-Rank menghasilkan p&lt;0,05, yang menandakan perbedaan signifikan secara statistik. Disimpulkan bahwa kemoterapi neoadjuvant efektif dalam mengecilkan ukuran tumor pada pasien kanker payudara stadium III. Penelitian ini diharapkan dapat menjadi rujukan dalam pemilihan regimen kemoterapi serta meningkatkan kualitas penanganan kanker payudara di Indonesia</p> 2025-10-01T00:00:00+07:00 Copyright (c) 2025 Dea Fauziah, Fajar Amirulah, Dini Permata Sari, Rangki Astiani https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/97 POLA PENGGUNAAN ANTIBIOTIK PADA PASIEN ANAK DENGAN COMMUNITY-ACQUIRED PNEUMONIA DI RUANG RAWAT INAP RSUD KABUPATEN KOLAKA TIMUR 2025-10-28T22:05:18+07:00 Muhammad Rahmat Masdin rahmatmasdin@gmail.com Harni Sartika Kamaruddin sartikaharni@gmail.com Ines Septiani Pratiwi Pratiwiines86@gmail.com Ulfa Anugrah ulfaanugrah22@gmail.com <p><em>Community-acquired pneumonia (CAP) is a major cause of morbidity and mortality in children. Antibiotics are the primary therapy for CAP; however, the choice of antibiotic type, dose, and duration can affect the success of therapy and the risk of resistance. This study was conducted to determine the pattern of antibiotic use in pediatric patients with CAP at RSUD Kabupaten Kolaka Timur. This retrospective descriptive study used medical records of pediatric patients treated in the inpatient ward of</em> <em>RSUD Kabupaten Kolaka Timur who were diagnosed with CAP in 2022. The results showed that the majority of pediatric patients diagnosed with CAP received combination therapy (57%) using cefotaxime and gentamicin (79.4%), while the most commonly given monotherapy (43%) was cefotaxime (47.1%). The conclusion of the study is that the combination therapy of cefotaxime and gentamicin is the most commonly given to pediatric patients with CAP in the inpatient ward of </em>RSUD Kabupaten Kolaka Timur<em>.</em></p> 2025-10-01T00:00:00+07:00 Copyright (c) 2025 Muhammad Rahmat Masdin, Harni Sartika Kamaruddin, Ines Septiani Pratiwi, Ulfa Anugrah https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/95 Analisis Efektivitas Biaya Terapi Antihipertensi di Indonesia: Systematic Literature Review Berdasarkan Parameter ACER dan ICER Periode 2019–2024” 2025-10-18T09:01:07+07:00 honifa honifa.0422119404@unpak.ac.id Cyntia wulandari cyntiawulandari@unpak.ac.id <p><em>This study aims to systematically review the literature analyzing the cost-effectiveness of antihypertensive therapy in Indonesia for the 2019–2024 period and to identify the most cost-effective regimens based on Average Cost-Effectiveness Ratio (ACER) and Incremental Cost-Effectiveness Ratio (ICER). The systematic review was conducted following the PRISMA 2020 guidelines, with literature searches performed on PubMed, Google Scholar, and ScienceDirect using the keywords “cost-effectiveness,” “antihypertensive,” “ACER,” “ICER,” and “Indonesia.” Selected articles were assessed for relevance, data completeness, and methodological quality.The findings indicate that therapies based on Calcium Channel Blockers (CCB), particularly amlodipine, and the combination of ACE inhibitors (ACEI) + CCB, are the most cost-effective regimens compared to Angiotensin Receptor Blockers (ARB), diuretics, and branded drugs. These regimens provide higher clinical effectiveness at a lower treatment cost, especially among patients with uncomplicated hypertension or comorbid diabetes mellitus. Furthermore, the use of generic drugs consistently demonstrated lower ICER values compared to branded products, supporting cost-efficiency policies under Indonesia’s National Health Insurance (BPJS Kesehatan). These findings may serve as a foundation for developing the National Formulary and cost-efficient drug procurement policies. Limitations include the narrow range of studies and the absence of Quality-Adjusted Life Years (QALY) and indirect cost analyses, suggesting future research should adopt a multicenter cost-utility approach for more comprehensive evaluation</em></p> 2025-10-01T00:00:00+07:00 Copyright (c) 2025 honifa, Cyntia wulandari https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/98 EVALUASI ADRs (ADVERSE DRUG REACTIONS) PADA PASIEN ASMA RAWAT INAP DI RUMAH SAKIT X KUDUS 2025-10-30T13:30:31+07:00 Heni Setyoningsih henisetyo82@gmail.com Shelli Apriliyani shelli@gmail.com Hasty Martha Wijaya martha.cendekia@gmail.com <p><em>Asthma is a chronic inflammatory disorder of the respiratory tract. Adverse drug reactions (ADRs) are responses to adverse and unwanted drugs that occur at doses normally used in humans for the prevention, diagnosis, or therapy of disease or for physiological function modification. The purpose of this study was to determine the type of therapy that was often used and to determine the number of ADRs in asthma patients hospitalized at X Hospital in 2021. This study was an observational study using a non-experimental descriptive method with retrospective data collection. The data was taken from medical record searches and side effects monitoring sheet. The patients in the inclusion criteria were 42 patients; their data were processed statistically using univariate analysis with a frequency test. The results showed that the types of therapy that were often used in the treatment of asthma were topical therapy 51 (35.7%), parenteral therapy 49 (34.3%), while oral therapy was 43 (30.1%). As well as the number of ADRs (Advers Drug Reactions) with complaints of chest palpitations and tremors on salbutamol treatment as many as 4 patients (23.5%), nausea, vomiting on aminophylline treatment as many as 4 patients (23.5%), digestive disorders on methylprednisolone as many as 2 patients (11.8%), and the incidence of dry or painful mouth and throat, hoarseness on ventolin nebulizer treatment was 7 patients (41.2%).</em></p> 2025-10-01T00:00:00+07:00 Copyright (c) 2025 Heni Setyoningsih, Shelli Apriliyani, Hasty Martha Wijaya https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/104 PENGARUH VARIASI SUHU DAN DURASI PENYIMPANAN TERHADAP KANDUNGAN VITAMIN C JERUK SULIKI (Citrus sinensis L.) DENGAN METODE TITRASI IODIMETRI 2025-11-08T07:58:37+07:00 Dewi Nofita dewinofita85@gmail.com Dirsa Jorenda DirsaJorenda@mail.com Amelia Ramadani AmeliaRamadani@mail.com <p>Suliki Orange (<em>Citrus sinensis</em> L.) represents a tropical fruit variety abundant in ascorbic acid, though its concentration undergoes changes throughout storage periods. The present investigation examines how temperature conditions and storage intervals influence vitamin C levels in Suliki oranges through iodimetric analysis. Fruit specimens underwent storage at two distinct temperature settings (ambient and refrigerated conditions) across varying durations of 1, 4, and 8 days. Preliminary qualitative analysis utilizing Fehling A and B reagents demonstrated color transformation to brownish-green, confirming vitamin C presence. Findings revealed that ambient temperature storage maintained vitamin C concentrations between 23.7-25.8 mg/100 g, peaking at day 4 (25.8 mg/100 g). During ambient storage spanning days 1-4, vitamin C levels rose from 25 mg/100 g to 26 mg/100 g. Contrastingly, refrigerated storage exhibited declining patterns from 25.20 mg/100 g (day 1) to 22.35 mg/100 g (day 4). These findings demonstrate that both temperature and storage intervals significantly impact vitamin C stability in Suliki oranges, with brief ambient storage periods showing superior vitamin C preservation or enhancement relative to refrigerated conditions.</p> 2025-10-01T00:00:00+07:00 Copyright (c) 2025 Dewi Nofita, Dirsa Jorenda, Amelia Ramadani https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/103 Cardiorenal Syndrome pada Pasien Dewasa dengan Gagal Ginjal Kronis dan Gagal Jantung: Systematic Literature Review 2025-11-03T20:56:24+07:00 Dea Fauziah fauziahdea22@gmail.com Marco Develsio develsio@gmail.com Brigita Victoria Victoria@mail.com Rosna Elfrina Sitompul Sitompul@mail.com Yuni Arsita Fitriyani YuniArsitaFitriyani@mail.com Nhila Putri Evani NhilaPutriEvani6@mail.com Diana Laila Ramatillah DianaLailaRamatillah7@mail.com Norman Dyanto NormanDyanto8@mail.com <p>Cardiorenal Syndrome (CRS) represents a complex pathophysiological dysfunction involving both the heart and kidneys, highly prevalent among adult patients with chronic kidney disease (CKD) and heart failure (HF). This bidirectional interaction exacerbates both conditions, leading to markedly increased morbidity and mortality. This systematic literature review, which followed the PRISMA framework to synthesize current evidence on the mechanisms, diagnosis, and management of CRS in adult populations. The findings indicate that CRS in this group is predominantly chronic (Types 2 and 4), driven by neurohormonal activation, chronic inflammation, and oxidative stress. Diagnostic challenges persist, requiring the integration of novel biomarkers with precise clinical assessment. In terms of management, an individualized and multidisciplinary approach is essential. Optimization of guideline-directed medical therapies, such as ACEi/ARB/ARNI and beta-blockers, must be accompanied by careful renal monitoring. While diuretics remain the cornerstone for volume control, novel treatments like SGLT2 inhibitors have shown significant benefits in improving both cardiovascular and renal outcomes simultaneously. In conclusion, effective CRS management requires a multidisciplinary strategy that balances cardioprotective and renoprotective effects. Further research is warranted to refine diagnostic tools and optimize therapeutic strategies to improve long-term patient outcomes.</p> 2025-10-01T00:00:00+07:00 Copyright (c) 2025 Dea Fauziah, Marco Develsio, Brigita Victoria, Rosna Elfrina Sitompul, Yuni Arsita Fitriyani, Nhila Putri Evani, Diana Laila Ramatillah, Norman Dyanto https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/102 FORMULASI DAN EVALUASI SEDIAAN LIPBALM EKSTRAK ETANOL BUNGA KEMBANG SEPATU KUNCUP (Malvaviscus arboreus Cav.) 2025-11-05T09:52:55+07:00 Mia Arifka arifkaamia@gmail.com Dewi Nofita DewiNofita1@mail.com Nurul Fadhila NurulFadhila1@mail.com Tri Ayu Ningsih TriAyuNingsih1@mail.com <p><em>Lip skin can experience damage such as dry and chapped lips if exposed to sunlight containing ultraviolet. Damaged lip skin can be repaired with antioxidant compounds. One of the plants that is effective as an antioxidant is the bud hibiscus flower (Malvaviscus arboreus Cav.). This study aims to formulate a lip balm preparation containing bud hibiscus extract with varying extract concentrations, namely Formulation 1 (2%), Formulation 2 (4%), and Formulation 3 (6%). The evaluations carried out in this study were organoleptic tests, homogeneity tests, pH tests, spreadability tests, and smearing power tests. In this study, organoleptic, homogeneity, pH, spreadability, and smearing power tests were carried out. The results showed that the bud hibiscus flower extract can be formulated into a lip balm preparation. Physical tests of the preparation showed that the semi-solid preparation was purple in color with a rose oil aroma, a homogeneous texture, a pH of 5 and a spreadability of 3–5 cm, so it can be said to meet the standards as a lip balm preparation for lip moisturizer</em></p> 2025-10-01T00:00:00+07:00 Copyright (c) 2025 Mia Arifka, Dewi Nofita, Nurul Fadhila, Tri Ayu Ningsih https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/105 UJI TOKSISITAS HASIL FRAKSINASI EKSTRAK DAUN GANDARIA (Bouea macrophylla Griff) TERHADAP LARVA UDANG (Artemia salina Leach) DENGAN METODE BSLT (Brine Shrimp Lethality Test) 2025-11-10T08:37:40+07:00 Wahyu Nuraini Hasmar wahyunurainihasmar@gmail.com Michelia Victoria MicheliaVictoria2@mail.com Nurul Inayah NurulInayah2@mail.com Tamzil Azizi Musdar TamzilAziziMusdar1@mail.com Ika Lismayani Ilyas IkaLismayaniIlyas@mail.com Muhammad Israwan Aziz MuhammadIsrawanAziz@mail.com <p><strong><em>Bouea macrophylla Griff (gandaria)</em></strong><em> is a rare fruit plant native to Maluku that possesses scientific potential which has not been widely explored. Its leaves contain quercetin, a flavonoid known to have antioxidant, anti-inflammatory, anticancer, antimicrobial, cardioprotective, and antidiabetic effects at non-toxic doses. This study evaluated the toxicity of leaf extract fractions in ethanol, ethyl acetate, and n-hexane solvents using the <strong>Brine Shrimp Lethality Test (BSLT)</strong> to determine the LC₅₀ value against Artemia salina larvae. The results showed that the n-hexane and ethanol fractions were toxic, with LC₅₀ values of 61.66 µg/mL and 170.61 µg/mL, respectively, while the ethyl acetate fraction exhibited much lower toxicity (LC₅₀ = 1425.61 µg/mL). This study indicates that the n-hexane and ethanol fractions have significant cytotoxic activity and therefore have the potential to inhibit cancer cell growth. </em></p> 2025-10-01T00:00:00+07:00 Copyright (c) 2025 Wahyu Nuraini Hasmar, Michelia Victoria, Nurul Inayah, Tamzil Azizi Musdar, Ika Lismayani Ilyas , Muhammad Israwan Aziz https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/108 Hubungan Pengetahuan dan Perilaku Tenaga Vokasi Farmasi Dalam Pengelolaan Obat High Alert di Instalasi Farmasi RS X Kota Payakumbuh 2025-11-22T11:54:33+07:00 Renatalia Fika fikarenatalia@gmail.com Mevy Trisna mevytrisna@gmail.com Hanna Hannisa fikarenatalia@gmail.com Muhajri Agusfina fikarenatalia@gmail.com Yonrizon fikarenatalia@gmail.com Desy Kurniaty fikarenatalia@gmail.com <p><em>High Alert Medication is a medication that needs to be watched out for because it can cause serious errors/mistakes (sentinel events), and has a high risk of causing undesirable effects (adverse outcomes). High alert medication management is a series of activities regulating medications that are specifically in the category of high-risk medications that can cause harm. This study aims to determine the knowledge of pharmacy vocational personnel and behavior in managing high alert medications at Dr. Adnaan WD Regional General Hospital, Payakumbuh City. This study is a descriptive analytical study with a cross-sectional design. The population in this study were all pharmacy vocational personnel at Dr. Adnaan WD Regional General Hospital, Payakumbuh City, totaling 22 people. Data analysis used the Chi-square test. The results showed that the level of knowledge of pharmacy vocational personnel regarding the management of high alert medications had good knowledge results (77%), sufficient (23%). For the behavior of pharmacy vocational personnel, it was good (77%), sufficient (23%). p.value = 0.024. The conclusion of this study is that there is a relationship between knowledge and behavior of pharmacy vocational staff in managing high-alert medications at RS X, Payakumbuh City.</em></p> 2025-10-01T00:00:00+07:00 Copyright (c) 2025 Mevy, Fika, Hanna, Muhajri, Yon, Desy https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/68 GAMBARAN PENGGUNAAN OBAT GASTRITIS PADA PASIEN RAWAT INAP DI RUMAH SAKIT X DI KOTA TANJUNGPINANG 2025-11-21T08:38:42+07:00 Yonrizon yonrizon72@gmail.com Renatalia Fika Fika@mail.com Riky Riyandani RikyRiyandani@mail.com <p>Gastritis is an inflammation of the stomach caused by irritation, infection, irregular eating patterns, and poor dietary habits such as consuming spicy foods, eating high-protein meals excessively, and drinking too much coffee. According to the WHO, the global incidence of gastritis is 40.8%. Based on the 2018 Indonesian Health Profile, gastritis is one of the ten most common diseases among hospitalized patients in Indonesia, with a total of 30,154 cases (4.9%). The purpose of this study was to describe the pattern of gastritis drug use in inpatients at Tanjungpinang X Hospital. This research was conducted using a retrospective method at Tanjungpinang X Hospital during the period July–December 2023. The instrument used was patient medical record data, and sampling was performed using a random sampling technique. A total of 190 patients met the inclusion criteria. The results showed that the distribution of gastritis patients by gender consisted of 93 men (48.94%) and 97 women (51.06%). Based on age, the highest number of patients fell into the late-elderly group (56–65 years), totaling 102 individuals (53.68%). In terms of drug classes, the most frequently used medications were Proton Pump Inhibitors (PPIs), with 158 instances of use (66.94%).</p> 2025-10-01T00:00:00+07:00 Copyright (c) 2025 Yonrizon, Renatalia Fika , Riky Riyandani https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/110 ANALISIS KINERJA MANAJEMEN PENGGUNAAN OBAT: EVALUASI PERESEPAN ANTIBIOTIK ISPA NON-PNEUMONIA DI PUSKESMAS INDONESIA (STUDI LITERATUR 2021–2025) 2025-11-29T08:54:47+07:00 Aprillia Puspitasari Tunggadewi farilli4n@gmail.com Mera Putri Pratitis MeraPutriPratitis2@mail.com Priska Juanita Pakingki PriskaJuanitaPakingki3@mail.com Setiaji Wisnu Wardana SetiajiWisnuWardana@mail.com <p><em>Non-pneumonia Acute Respiratory Infection (ARI) is a high-volume process area in Primary Health Care facilities (Puskesmas) and serves as a critical Key Performance Indicator (KPI) for antibiotic stewardship. This Systematic Literature Review (SLR) evaluates drug management performance across various Primary Health Care in Indonesia for the 2021-2025 period, utilizing data from 10 original research articles. The results indicate significant operational variance, with antibiotic usage rates ranging sharply from 4% to 65.2%. While several high-performing units have achieved the national efficiency target (≤20%), the majority exhibit weak prescriptive control, which escalates organizational risks related to Antimicrobial Resistance (AMR) and financial inefficiency. The first-line drug, Amoxicillin, dominates the formulary; however, a concerning regional trend toward the use of less efficient second-line agents (Cefadroxil) was detected. It is concluded that proactive managerial intervention is necessary, emphasizing the need for Pharmacists to conduct routine prospective prescription audits and strengthen inter-professional compliance to ensure resource optimization and clinical outcomes.</em></p> 2025-10-01T00:00:00+07:00 Copyright (c) 2025 Aprillia Puspitasari Tunggadewi, Mera Putri Pratitis, Priska Juanita Pakingki, Setiaji Wisnu Wardana https://www.journal.stisadwifarma.ac.id/index.php/jps/article/view/109 ANALISA INDEKS GLIKEMIK BIJI JAGUNG MANIS (Zea mays saccharata Sturt.)Rebus dan BIJI JAGUNG LOKAL (Zea mays) Rebus TERHADAP TIKUS PUTIH JANTAN (Rattus novegicus) 2025-11-28T13:16:34+07:00 Mevy Trisna mevy.trisna89@gmail.com Khaula Zhafira fikarenatalia@gmail.com Renatalia Fika fikarenatalia@gmail.com Muhajri Agusfina fikarenatalia@gmail.com Trie Yuni Elfasyari fikarenatalia@gmail.com Zulfisa zulfisa.fisa@gmail.com <p>This study aims to analyze the glycemic index (GI) value of boiled sweet corn (Zea mays saccharata Sturt.) and local corn (Zea mays) in male white rats (Rattus norvegicus). The method used is measuring blood glucose levels at 0, 30, 60, 90, and 120 minutes after sample administration, then calculating the area under the curve (AUC) to obtain the GI value. The results showed that boiled sweet corn kernels had a GI value of 74.34% and boiled local corn kernels 75.28%, both of which are classified as high glycemic index. This high GI value is influenced by starch content, dietary fiber content, and processing methods. Based on these results, it is recommended that people with diabetes mellitus limit their consumption of these two types of boiled corn</p> 2025-10-01T00:00:00+07:00 Copyright (c) 2025 Mevy Trisna, Khaula Zhafira, Renatalia Fika, Muhajri Agusfina, Trie Yuni Elfasyari, Zulfisa